what exactly do you mean by this:
Although the collection supports multiple Page objects to be associated with a single Issue object, I'm trying to set up a simple DataGridView which binds through a binding source, to the IssueCollection object.
Perhaps I miss something, but I don't quite follow this.
Also, these scenario's can get complex really quickly, so if you have an example form which illustrates what you want (to some extend), it would be great as from the posts you posted, I don't fully understand what you're trying to accomplish. Binding a collection to a grid is pretty straight forward, so I don't think that's the bottleneck so it must be something else.