Here are the general steps that I followed:
Create new SD.LLBLGen.Pro.ORMSupportClasses.PredicateExpression, initialized to null;
Assign a new PredicateExpression based on the comparison (greater than) of a field that is on the base entity.
AND the expression with a comparison of a field on a related entity
Create a PrefetchPath for the base entity.
Create a RelationCollection and add the relation that links the base entity to the related entity
Add to the PrefetchPath the path for the related entity, 0 maxItems, the previously created predicate, and the RelationCollection
Call GetMulti()
Get an exception