Hmm, that's a bit difficult. The thing is that the TDL interpreter has a regex which has either ' or // implemented as comment marker See the TDLInterpreter class at the top for the Regex. Adding '#' will then work.
Does python have block comment markers? Like /* */ in C# or <!-- --> in html? If so, you could wrap the marker in a block: (html here)
<!--
<[ UserCoreRegion .. ]>
// __LLBLGENPRO...
-->
// user code
<!--
// __LLBLGENPro...
<[ EndUserCodeRegion]>
-->