I think I figured it out.
EntityCollection<OrderManifestsEntity> orderManifests = new EntityCollection<OrderManifestsEntity>();
PrefetchPath2 prefetchPath = new PrefetchPath2(EntityType.OrderManifestsEntity);
IPrefetchPathElement2 prefetchPathOrders = prefetchPath.Add(OrderManifestsEntity.PrefetchPathOrdersList_);
prefetchPathOrders.SubPath.Add(OrdersEntity.PrefetchPathAdministerTime_).SubPath.Add(AdministerTimesEntity.PrefetchPathAdministerTimeType_);
prefetchPathOrders.SubPath.Add(OrdersEntity.PrefetchPathPatientDiagnosis_).SubPath.Add(PatientDiagnosesEntity.PrefetchPathDiagnoses);
prefetchPathOrders.SubPath.Add(OrdersEntity.PrefetchPathEncounteredBy);
prefetchPathOrders.SubPath.Add(LabOrdersEntity.PrefetchPathLab_);
prefetchPathOrders.SubPath.Add(MedicationOrderEntity.PrefetchPathDrug_);
LLBLGEN is smart!!!!!